I'll leave the detailed analysis to others. My quick take, mostly based on comparing baseline characteristics of each group (Table 1), interventions in each group (Table 2), and outcomes (Table 3): ProMISe is a lot like ProCESS and ARISE.
The groups were similar, and the outcomes were similar, but most notably, the interventions were similar.
My bottom line interpretation remains the same; the keys in sepsis are:
- early identification
- early antibiotics
- early aggressive resuscitation (particularly fluids)
What ProCESS, ARISE, and ProMISe really tell us is that if you do all the things that are on a protocol, it doesn't matter whether or not you have a protocol.*
Like with ProCESS, it's a little tricky to decipher what fluids each subgroup actually got. I think Table S7 in the Supplemental Appendix is key:
*more on protocols from me, re: ProCESS
**Correction: just noticed the terminal "e" is not capitalized. Oh well.